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KMID : 0366219880230020393
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Korean Journal of Hematology
1988 Volume.23 No. 2 p.393 ~ p.400
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The Titer of IgG Anti-A/B oin the Serum of Group O Mothers of ABO Hemolytic Disease of the Newborn
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Abstract
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With the declining incidence of Rh hemolytic disease since the introduction of Rh
immune globulin therapy, ABO incompatibility has become one of the most common
cause of hemolytic disease of the newborn requiring therapy at many institutions.
Previous studies have shown a poor correlation between serologic tests on cord blood
and clinical course in affected infants.
In an attempt to identify any correlation between clinical severity of ABO hemolytic
disease of the newborn and various laboratory parameters tested, a retrospective
study was undertaken on 33 cases of ABO hemolytic disease out of 2767 deliveries
over 17-month period.
The results are summarized as follows.
1. Among thirty-three ABO hemolytic disease of the newborn, 21 infants were
AO-HDN and 12 were BO-HDN,4 total of seven infants required exchange transfusion,
1 case of AO-HDN and 6 cases of BO-HDN.
2. Male to female ratio was 1.8 : 1.
3. The onset of jaundice was noted within 24 hours after birth in 24 cases and within
48 hours in 14 cases.
4. The degree of jaundice in infants of BO-HDN was 18.6±4.2㎎/dl and this was
significantly higher(P<0.05) than that of AO-HDN(15.3±2.8㎎/dl).
5. The degree of hyperbilirubinemia was significantly higher(p<0.1) in the second
born baby(18.26±4.81㎎/d1) than that of first born baby(15.87±3.53㎎/d1).
6. There was no correlation between the degree of positive direct antiglobulin test and
maximum serum bilirubin level.
7. The IgG anti-A/B titers of the mothers were 1 : 512-1 : 4096, but no significant
correlation was found between the titer of IgG and the degree of positive antiglobulin
test.
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